HPLC/UV

Description

mpa and mpa_imp_07 were analyzed as follows: A YMC-Pack A312 (6 mm x 150 mm) column was eluted with a mobile phase composed of 0.01 N H3PO4(aq)/acetonitrile (2:3) at a flow rate of 1 ml/min. The retention time of MPA was 15.5 min, and that of mpa_imp_07 (Megestrol acetate) was 14.5 min. The UV detection wavelength was set at 240 nm.

References

  1. Ohtsu; Fujii; Wakita; Igarashi; Itoh; Imoto; Kohagura; Sasaki. Pharmacokinetic study of low- versus high-dose medroxyprogesterone acetate (MPA) in women. Cancer Chemotherapy and Pharmacology. 1998; 42:1/8/2016
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