Quinestrol is a synthetic estrogen and prodrug of ethinyl estradiol. It is used in hormone replacement therapy and in the treatment of some cancers, as well as in combined oral contraceptives in China and Argentina.
Abbreviation
EE3CPE
Names
ethinyl estradiol 3-cyclopentyl ether
3-(cyclopentyloxy)-17β-ethynylestra-1,3,5(10)-trien-17-ol
CASRN
152-43-2
PubChem CID
9046
ECHA InfoCard
IUPHAR/BPS
7097
DrugBank Accession Number
DB04575
References
UNII
JR0N7XD5GZ
KEGG Entry Number
D00576
Wikipedia Entry Name
Quinestrol
ChEBI ID
CHEBI:8716
ChEMBL ID
CHEMBL1201165
ChemSpider ID
8694
Molecular Formula
C25H32O2
Molecular Weight
364.529 g/mol
Melting Point
107.5 °C
GHS Hazard Code(s)
Class | Category | Code | Description |
---|---|---|---|
Acute Oral Toxicity | 4 | H302 | Harmful if swallowed |
Acute Dermal Toxicity | 4 | H312 | Harmful in contact with skin |
Acute Inhalation Toxicity | 4 | H332 | Harmful if inhaled |
Carcinogenicity | 1B | H350 | May cause cancer |
Carcinogenicity | 2 | H351 | Suspected of causing cancer if inhaled |
Reproductive Toxicity | 1A | H360 | May damage fertility or the unborn child |
Reproductive Toxicity, Effects On or Via Lactation | H362 | May cause harm to breast-fed children |
Estrogen Receptor Activity
Agonist
Primary metabolite of mestranol and quinestrol. Also a minor metabolite of norethindrone (0.7 and 1.0% of norethindrone converted to ethinyl estradiol at doses of 5 and 10 mg, respectively).