Norethindrone acetate (NETA), or norethisterone acetate, is an ester prodrug of norethindrone. It is a synthetic progestogen used in place of norethindrone in some hormonal contraceptives.
Wikipedia Entry Name
white or yellowish-white, odorless, crystalline powder
Practically insoluble in water (1 g in > 10 L). Soluble in chloroform (1 part in <1), ethanol (1 part in 10), dioxane (1 part in 2), and diethyl ether (1 part in 18).
Specific Optical Rotation
-32° to -28°
Not found to be mutagenic in the Ames Salmonella/microsome direct plate incorporation protocol.
Clastogenic to human lymphocytes as determined chromosome aberrations and sister chromatid exchanges. The Ames Salmonella assay did not indicate genotoxicity.
Norethindrone acetate, norethindrone enanthate, lynestrenol, and ethynodiol diacetate (and to a very small extent, norethynodrel) are prodrugs of norethindrone. Conversion of lynestrenol to ethynodiol to norethindrone facilitated by CYP2C9, CYP2C19, and CYP3A4. Conversion of norethynodrel to norethindrone is accomplished by either non-enzymatic or enzymatic ketosteroid isomerization.