Norgestrel is a synthetic progestogen used in combined oral contraceptives. It is a racemic mix of the stereoisomers dextronorgestrel and levonorgestrel. As dextronorgestrel is biologically inactive, the behavior of norgestrel is identical to that of levonorgestrel.
DrugBank Accession Number
KEGG Entry Number
Wikipedia Entry Name
White or almost white crystalline powder
Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in alcohol.
Specific Optical Rotation
BP: +0.05° to -0.05°. 0.5 g in methylene chloride diluted to 10.0 mL
IARC: -0.1 to +0.1° in chloroform
GHS Hazard Code(s)
|Carcinogenicity||2||H351||Suspected of causing cancer if inhaled|
|Reproductive Toxicity||1A||H360FD||May damage fertility. May damage the unborn child|
|Reproductive Toxicity, Effects On or Via Lactation||H362||May cause harm to breast-fed children|
Found to affect genetic material of human lymphocyte chromosomes as measured by chromosomal aberrations, sister chromatid exchanges, and cell growth kinetics.
Progesterone Receptor Activity
Serum Protein Binding
Binds to SHBG