1. APIs
  2. Ethynodiol Diacetate
  3. Metabolites

Ethynodiol Diacetate Metabolites

Name Structure Notes
Other Ethynodiol Diacetate Metabolites As ethynodiol diacetate is a prodrug of norethindrone, metabolites of norethindrone are formed after administration of ethynodiol diacetate. These metabolites include all 4 isomers of 3,5-tetrahydronorethindrone: 3α,5α-, 3β,5α, 3α,5β, and 3β,5β.
3β-Hydroxynorethindrone Acetate structure Reported as in vitro metabolite of ethynodiol diacetate by human liver cells.
Norethindrone Acetate structure Reported as in vitro metabolite of ethynodiol diacetate by human liver cells.
Norethindrone structure Norethindrone acetate, norethindrone enanthate, lynestrenol, and ethynodiol diacetate (and to a very small extent, norethynodrel) are prodrugs of norethindrone. Conversion of lynestrenol to ethynodiol to norethindrone facilitated by CYP2C9, CYP2C19, and CYP3A4. Conversion of norethynodrel to norethindrone is accomplished by either non-enzymatic or enzymatic ketosteroid isomerization.