1. APIs
  2. Ethynodiol Diacetate
  3. Impurities
  4. (E)-17α-Ethinyl-4-estrene-3β,17-diol-3-acetate-17-(3′-acetoxy-2′-butenoate)

(E)-17α-Ethinyl-4-estrene-3β,17-diol-3-acetate-17-(3′-acetoxy-2′-butenoate)

Structure

Other Names & Identifiers

  • (E)-17α-ethynyl-4-oestrene-3β,17-diol-3-acetate-17-(3'-acetoxy-2'-butenoate)

Notes

Side product of the acetylations catalyzed by 4-dimethylaminopyridine.

References

  1. Görög, S.; Balogh, G.; Gazdag, M. Estimation of Impurity Profiles of Drugs and Related Materials. Part VIII: Combined Application of High- Performance Liquid Chromatography and NMR Spectroscopy in the Impurity Profiling of Drugs. J. Pharm. Biomed. Anal. 1991, 9 (10–12), 829–833. (View all citations for this reference)
  2. Babják, M.; Balogh, G.; Gazdag, M.; Görög, S. Estimation of Impurity Profiles of Drugs and Related Materials: Part XXI. HPLC/UV/MS Study of the Impurity Profile of Ethynodiol Diacetate. J. Pharm. Biomed. Anal. 2002, 29 (6), 1153–1157. (View all citations for this reference)
  3. Görög, S. Industrial and Compendial Steroid Analysis. In Steroid Analysis; Springer Netherlands: Dordrecht, 2010; pp 1097–1153. (View all citations for this reference)