1. APIs
  2. Estradiol
  3. Impurities
  4. E2 Impurity 01

E2 Impurity 01

Structure

MOL SDF CML

Notes

Not identified in pharmacopoeias. ID in reference: 2a. Formed from oxidative degradation of estradiol. Can be further degraded to E2 Impurity 04 (mechanism: E2 -> Impurity 1 + 2 + 3. Then 1 -> 4 -> 5 -> 6).

Molecular Formula

C18H24O4

References

Molecular Weight

304.39 g/mol

References

References

  1. Beni, Z.; Hada, V.; Varga, E.; Maho, S.; Aranyi, A.; Szantay, C., New oxidative decomposition mechanism of estradiol through the structural characterization of a minute impurity and its degradants. J. Pharm. Biomed. Anal. 2013, 78-79, 183-189.
    2. (View all citations for this reference)