1. APIs
  2. Estradiol
  3. Impurities
  4. E2 Impurity 06

E2 Impurity 06

Structure

MOL SDF CML

Notes

Not identified in pharmacopoeias. ID in reference: 4a. Formed from further degradation of E2 impurity 05 (mechanism: E2 -> Impurity 1 + 2 + 3. Then 1 -> 4 -> 5 -> 6).

Molecular Formula

C18H22O3

References

Molecular Weight

286.37 g/mol

References

Spectra

1H NMR, 13C NMR

library_books

References

  1. Beni, Z.; Hada, V.; Varga, E.; Maho, S.; Aranyi, A.; Szantay, C., New oxidative decomposition mechanism of estradiol through the structural characterization of a minute impurity and its degradants. J. Pharm. Biomed. Anal. 2013, 78-79, 183-189.
    2. (View all citations for this reference)

References

  1. Beni, Z.; Hada, V.; Varga, E.; Maho, S.; Aranyi, A.; Szantay, C., New oxidative decomposition mechanism of estradiol through the structural characterization of a minute impurity and its degradants. J. Pharm. Biomed. Anal. 2013, 78-79, 183-189.
    2. (View all citations for this reference)