6α-Hydroxyethinyl Estradiol
Structure
Other Names & Identifiers
- BP Ethinylestradiol Impurity E
- 6α-hydroxy-ethinylestradiol
- 19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,6&alpha,17-triol
CASRN
27521-34-2
Molecular Formula
C20H24O3
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Molecular Weight
312.409 g/mol
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Analytical Data
Fluorescence (215/315 nm), HPLC
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Melting Point
158 - 161° C
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References
- Rao ,P.N. Steroids. 1974; 23:173 - 183 (View all citations for this reference)
Structural Difference from API
One of the H's at C6 of EE is replaced with an OH group.
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References
- British Pharmacopoeia 2017: Ethinylestradiol monograph (View all citations for this reference)
Source from API
Oxidative hydroxylation of EE at C6.
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References
- British Pharmacopoeia 2017: Ethinylestradiol monograph (View all citations for this reference)
Reaxys ID #
5597221
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Limits
0.10%
References
- United States Pharmacopoeia 39, 2015 Revision Bulletin: Drospirenone and Ethinyl Estradiol Tablets. (View all citations for this reference)
- British Pharmacopoeia 2017: Ethinylestradiol monograph (View all citations for this reference)
- Segmuller, B. E.; Armstrong, B. L.; Dunphy, R.; Oyler, A. R. Identification of Autoxidation and Photodegradation Products of Ethynylestradiol by on-Line HPLC-NMR and HPLC-MS. J. Pharm. Biomed. Anal. 2000, 23 (5), 927–937. (View all citations for this reference)