1. APIs
  2. Ethinyl Estradiol
  3. Impurities
  4. 19-Nor-17α-pregn-1,3,5(10),6-tetraen-20-yne-3,17-diol

19-Nor-17α-pregn-1,3,5(10),6-tetraen-20-yne-3,17-diol

Structure

MOL SDF CML

Other Names & Identifiers

  • BP Ethinylestradiol Impurity I
  • 6,7-dehydro ethynyl estradiol
  • Δ6-ethinyl estradiol
  • 3,17β-dihydroxy-19-norpregna-1,3,5(10),6-tetraene-20-yne
  • Δ6-dehydroethynylestradiol

CASRN

67703-68-8

Molecular Formula

C20H22O2

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References

  1. National Center for Biotechnology Information. PubChem Compound Database; CID=11208630. (View all citations for this reference)

Molecular Weight

294.393 g/mol

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References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)

Melting Point

181.8 - 183.7° C

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References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)

CAS Number

67703-68-8

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References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)

Structural Difference from API

The C6-C7 single bond in EE is converted to a C6=C7 double bond.

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References

  1. British Pharmacopoeia 2017: Ethinylestradiol monograph
    2. (View all citations for this reference)

Source from API

Oxidation

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References

  1. British Pharmacopoeia 2017: Ethinylestradiol monograph
    2. (View all citations for this reference)

Pub Chem CID Number

11208630

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References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)
  2. National Center for Biotechnology Information. PubChem Compound Database; CID=11208630. (View all citations for this reference)

Reaxys ID Number

6517822

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References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)

Limits

0.2% (EP 7.4)

References

  1. European Pharmacopoeia 8.2 Ethinyl Estradiol
    2. (View all citations for this reference)
  2. British Pharmacopoeia 2017: Ethinylestradiol monograph
    3. (View all citations for this reference)
  3. Segmuller, B. E.; Armstrong, B. L.; Dunphy, R.; Oyler, A. R. Identification of Autoxidation and Photodegradation Products of Ethynylestradiol by on-Line HPLC-NMR and HPLC-MS. J. Pharm. Biomed. Anal. 2000, 23 (5), 927–937. (View all citations for this reference)