1. APIs
  2. Levonorgestrel
  3. Impurities
  4. 18-Methylnandrolone

18-Methylnandrolone

Structure

MOL SDF CML

Other Names & Identifiers

  • BP Levonorgestrel Impurity K
  • 13-ethyl-17β-hydroxygon-4-en-3-one

CASRN

793-55-5

Molecular Formula

C19H28O2

References

Molecular Weight

288.43 g/mol

References

Reaxys ID Number

5052494

References

Structural Difference from API

no ethynyl group at C17

References

Melting Point

159-160° C in diethyl ether

library_books

References

  1. Micheli RAH, Z. G.; Cohen, N.; Parrish, D. R.; Portland, L. A.; Sciamanna, W.; Scott, M. A.; Wehrli, P. A. Total synthesis of optically-active 19-norsteroids - (+)-estr-4-ene-3,17-dione and (+)-13β-ethylgon-4-ene-3,17-dione. Journal of Organic Chemistry. 1975; 40:675-81.
    2. (View all citations for this reference)

Optical Rotary Power

51.09° at 589 nm in chloroform, 25° C

library_books

References

  1. Micheli RAH, Z. G.; Cohen, N.; Parrish, D. R.; Portland, L. A.; Sciamanna, W.; Scott, M. A.; Wehrli, P. A. Total synthesis of optically-active 19-norsteroids - (+)-estr-4-ene-3,17-dione and (+)-13β-ethylgon-4-ene-3,17-dione. Journal of Organic Chemistry. 1975; 40:675-81.
    2. (View all citations for this reference)

Spectra

NMR, IR

library_books

References

  1. Bijoy PR, U.; Rao, Gsrs. DIRECT CONVERSION OF 13-BETA-ALKYLGONATETRAENES INTO 13-BETA-ALKYLGON-4-EN-3-ONES. Journal of the Chemical Society-Perkin Transactions 1. 1994:2331-3.
    2. (View all citations for this reference)

Spectra

UV-Vis Absorption

library_books

References

  1. Bijoy PR, U.; Rao, Gsrs. DIRECT CONVERSION OF 13-BETA-ALKYLGONATETRAENES INTO 13-BETA-ALKYLGON-4-EN-3-ONES. Journal of the Chemical Society-Perkin Transactions 1. 1994:2331-3.
    2. (View all citations for this reference)

Limits

0.3%

References

  1. British Pharmacopoeia 2017: Levonorgestrel monograph.
    2. (View all citations for this reference)