1. APIs
  2. Levonorgestrel
  3. Impurities
  4. Δ5-Levonorgestrel

Δ5-Levonorgestrel

Structure

MOL SDF CML

Other Names & Identifiers

  • BP Levonorgestrel Impurity P
  • 17α-ethinyl-13-ethyl-4-gonene-17-ol
  • 13-ethyl-18,19-dinor-17α-pregn-4-en-20-yn-17-ol

CASRN

100021-05-4

Molecular Formula

C21H28O2

References

Molecular Weight

312.45 g/mol

References

Reaxys ID Number

5580901

References

Structural Difference from API

double bond between C5 & C6 instead of between C4 & C5

References

Melting Point

127-129° C

library_books

References

  1. Williams, J. R.; Mattei, P. L.; Abdel-Magid, A.; Blount, J. F., Photochemistry of estr-4-en-3-ones: 17.beta.-hydroxy-4-estren-3-one, 17.beta.-acetoxy-4,9-estradien-3-one, 17.beta.-hydroxy-4,9,11-estratrien-3-one, and norgestrel. Photochemistry of 5.alpha.-estran-3-ones. The Journal of Organic Chemistry 1986, 51 (6), 769-773. (View all citations for this reference)

Spectra

NMR, IR, MS

library_books

References

  1. Williams, J. R.; Mattei, P. L.; Abdel-Magid, A.; Blount, J. F., Photochemistry of estr-4-en-3-ones: 17.beta.-hydroxy-4-estren-3-one, 17.beta.-acetoxy-4,9-estradien-3-one, 17.beta.-hydroxy-4,9,11-estratrien-3-one, and norgestrel. Photochemistry of 5.alpha.-estran-3-ones. The Journal of Organic Chemistry 1986, 51 (6), 769-773. (View all citations for this reference)

Limits

0.1%

References

  1. British Pharmacopoeia 2017: Levonorgestrel monograph.
    2. (View all citations for this reference)