1. APIs
  2. Levonorgestrel
  3. Impurities
  4. LNG Impurity 6

LNG Impurity 6

Structure

MOL SDF CML

CASRN

100021-07-6

Notes

Not identified in pharmacopoeias. Result of further photolysis of LNG Impurity 5 in methanol. LNG Impurity 7 is also formed.

Molecular Formula

C22H34O3

References

Molecular Weight

346.51 g/mol

References

Reaxys ID Number

5593129

References

Structural Difference from API

no double bond between C4 & C5

References

Source of Impurity

Product of photolysis in polar solvent (methanol)

library_books

References

  1. Williams, J. R.; Mattei, P. L.; Abdel-Magid, A.; Blount, J. F., Photochemistry of estr-4-en-3-ones: 17.beta.-hydroxy-4-estren-3-one, 17.beta.-acetoxy-4,9-estradien-3-one, 17.beta.-hydroxy-4,9,11-estratrien-3-one, and norgestrel. Photochemistry of 5.alpha.-estran-3-ones. The Journal of Organic Chemistry 1986, 51 (6), 769-773. (View all citations for this reference)

References

  1. Williams, J. R.; Mattei, P. L.; Abdel-Magid, A.; Blount, J. F., Photochemistry of estr-4-en-3-ones: 17.beta.-hydroxy-4-estren-3-one, 17.beta.-acetoxy-4,9-estradien-3-one, 17.beta.-hydroxy-4,9,11-estratrien-3-one, and norgestrel. Photochemistry of 5.alpha.-estran-3-ones. The Journal of Organic Chemistry 1986, 51 (6), 769-773. (View all citations for this reference)