1. APIs
  2. Nestorone
  3. Impurities
  4. Segesterone

Segesterone

Structure

Other Names & Identifiers

  • 16-methylene-17α-hydroxy-19-nor-pregn-4-ene-3,20-dione
  • 17α-hydroxy-16-methylene-19-norprogesterone
  • 17α-deacetylnestorone

CASRN

7690-08-6

Notes

Major degradant. RP-HPLC/MS.

Molecular Weight

328.452 g/mol

References

Structural Difference from Parent

Hydrolysis of 17α acyl group.

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References

  1. Ahmed, S. M.; Arcuri, F.; Li, F.; Moo-Young, A. J.; Monder, C., Accelerated stability studies on 16-methylene-17α-acetoxy-19-nor-pregn-4-ene-3,20-dione (Nestorone™). Steroids 1995, 60, 534-539.
    2. (View all citations for this reference)

Spectra

RP-HPLC/MS

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References

  1. Ahmed, S. M.; Arcuri, F.; Li, F.; Moo-Young, A. J.; Monder, C., Accelerated stability studies on 16-methylene-17α-acetoxy-19-nor-pregn-4-ene-3,20-dione (Nestorone™). Steroids 1995, 60, 534-539.
    2. (View all citations for this reference)

Source

Degradation

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References

  1. Ahmed, S. M.; Arcuri, F.; Li, F.; Moo-Young, A. J.; Monder, C., Accelerated stability studies on 16-methylene-17α-acetoxy-19-nor-pregn-4-ene-3,20-dione (Nestorone™). Steroids 1995, 60, 534-539.
    2. (View all citations for this reference)

References

  1. Ahmed, S. M.; Arcuri, F.; Li, F.; Moo-Young, A. J.; Monder, C., Accelerated stability studies on 16-methylene-17α-acetoxy-19-nor-pregn-4-ene-3,20-dione (Nestorone™). Steroids 1995, 60, 534-539.
    2. (View all citations for this reference)
  2. Ahmed, S. M. Effect of Cyclodextrins on the Chemical Stability of ST1435, a Contraceptive Steroid Progestin, in Aqueous Solution. J. Incl. Phenom. Mol. Recognit. Chem. 1997, 27 (1), 85–96. (View all citations for this reference)