1. APIs
  2. Norgestimate
  3. Impurities
  4. (Z)-Norelgestromin

(Z)-Norelgestromin

Structure

Other Names & Identifiers

  • BP Norgestimate Impurity D
  • (3Z)-13β-ethyl-3-(hydroxyimino)-18,19-dinor-17α-pregn-4-en-20-yn-17-ol

Notes

Both Z and E isomers formed.

Spectra

HPLC

library_books

References

  1. Mantena, B. P. V.; Rao, S. V.; Rao, K.; Ramakrishna, K.; Vittal, S. P., HPLC Method for Simultaneous Determination of Potential Impurities of Norgestimate and Ethinyl Estradiol in Combination Drug Product Using Sub-2 mu m Column. J. Liq. Chromatogr. Relat. Technol. 2015, 38 (10), 1014-1025.
    2. (View all citations for this reference)

Limits

0.1%

References

  1. Mantena, B. P. V.; Rao, S. V.; Rao, K.; Ramakrishna, K.; Vittal, S. P., HPLC Method for Simultaneous Determination of Potential Impurities of Norgestimate and Ethinyl Estradiol in Combination Drug Product Using Sub-2 mu m Column. J. Liq. Chromatogr. Relat. Technol. 2015, 38 (10), 1014-1025.
    2. (View all citations for this reference)
  2. British Pharmacopoeia 2017: Norgestimate monograph
    3. (View all citations for this reference)