1. APIs
  2. Medroxy­progesterone Acetate
  3. Metabolites
  4. 1β-hydroxymedroxyprogesterone acetate

1β-hydroxymedroxyprogesterone acetate

Structure

Source

Hydroxylation by cytochrome P450 3A4

Notes

Result of hydroxylation by cytochrome P450 3A4.

References

  1. DrugBank: Medroxyprogesterone Acetate.
    Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037     (View all citations for this reference)
  2. Chen, J.; Zhang, J.-W.; Yang, L.; Li, W. Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450. Chem. Pharm. Bull. (Tokyo). 2009, 57 (8), 835–839.
    3. (View all citations for this reference)
  3. Zhang, Jiang-Wei; Liu, Yong; Zhao, Jiu-Yang; Wang, Li-Ming; Ge, Guang-Bo; Gao, Yang; Li, Wei; Liu, Hong-Tao; Liu, Hui-Xin; Zhang, Yan-Yan; Sun, Jie; Yang, Ling. Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate. Drug Metabolism and Disposition. 2008; 36:2292 - 2298
    4. (View all citations for this reference)