1. APIs
  2. Etonogestrel
  3. Etonogestrel Metabolites
  4. 6β-Hydroxyetonogestrel

6β-Hydroxyetonogestrel

Structure

Source

Hydroxylation of etonogestrel.

Notes

Primary metabolite from human hepatic microsome metabolism. Likely formed by CYP3A4, as this enzyme is responsible for 6β-hydroxylation pathways in other steroids.

References

  1. Verhoeven, C. H. J.; Krebbers, S. F. M.; Wagenaars, G. N.; Vos, R. M. E. In Vitro and in Vivo Metabolism of Desogestrel in Several Species. DRUG Metab. Dispos. 1998, 26 (9), 927–936.
    2. (View all citations for this reference)
  2. Baydoun, E.; Wahab, A.; Shoaib, N.; Ahmad, M. S.; Abdel-Massih, R.; Smith, C.; Naveed, N.; Choudhary, M. I. Microbial Transformation of Contraceptive Drug Etonogestrel into New Metabolites with Cunninghamella Blakesleeana and Cunninghamella Echinulata. Steroids 2016, 115, 56–61. (View all citations for this reference)