1. APIs
  2. Norgestimate
  3. Metabolites
  4. Norelgestromin

Norelgestromin

Structure

CASRN

53016-31-2

Notes

Primary metabolite of norgestimate. Also called 17-deacetyl norgestimate or levonorgestrel-3-oxime.

Abbreviation

17-DA-NGM

library_books

References

  1. Wong, F. A.; Edom, R. W.; Duda, M.; Tischio, J. P.; Huang, M.; Juzwin, S.; Tegegne, G. Determination of Norgestimate and Its Metabolites in Human Serum Using High-Performance Liquid Chromatography with Tandem Mass Spectrometric Detection. J. Chromatogr. B Biomed. Sci. Appl. 1999, 734 (2), 247–256. (View all citations for this reference)

Names

levonorgestrel-3-oxime
17-deacetyl norgestimate

References

References

  1. MonoNessa: Norgestimate and Ethinyl Estradiol. DailyMed, a National Library of Medicines online database. (View all citations for this reference)
  2. Hammond, G. L.; Abrams, L. S.; Creasy, G. W.; Natarajan, J.; Allen, J. G.; Siiteri, P. K. Serum Distribution of the Major Metabolites of Norgestimate in Relation to Its Pharmacological Properties. Contraception 2003, 67 (2), 93–99. (View all citations for this reference)
  3. WHO International Agency for Research on Cancer: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 91: Combined Estrogen-Progestogen Contraceptives and Combined Estrogen-Progestogen Menopausal Therapy. 2007, Lyon, France. (View all citations for this reference)
  4. Wild, M. J.; Rudland, P. S.; Back, D. J. Metabolism of the Oral Contraceptive Steroids Ethynylestradiol, Norgestimate and 3-Ketodesogestrel by a Human Endometrial Cancer Cell Line (HEC-1A) and Endometrial Tissue in Vitro. J. Steroid Biochem. Mol. Biol. 1993, 45 (5), 407–420.
    5. (View all citations for this reference)
  5. Madden, S.; Back, D. J. Metabolism of Norgestimate by Human Gastrointestinal Mucosa and Liver Microsomes in Vitro. J. Steroid Biochem. Mol. Biol. 1991, 38 (4), 497–503. (View all citations for this reference)
  6. Wong, F. A.; Edom, R. W.; Duda, M.; Tischio, J. P.; Huang, M.; Juzwin, S.; Tegegne, G. Determination of Norgestimate and Its Metabolites in Human Serum Using High-Performance Liquid Chromatography with Tandem Mass Spectrometric Detection. J. Chromatogr. B Biomed. Sci. Appl. 1999, 734 (2), 247–256. (View all citations for this reference)
  7. Ahire, D.; Sinha, S.; Brock, B.; Iyer, R.; Mandlekar, S.; Subramanian, M. Metabolite Identification, Reaction Phenotyping, and Retrospective Drug-Drug Interaction Predictions of 17-Deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate. Drug Metab. Dispos. 2017, 45 (6), 676–685. (View all citations for this reference)
  8. Toxnet: Norgestimate. (View all citations for this reference)