Citations for: Desogestrel USP Safety Data Sheet.

Entry Type
Name
Value
Parent Entry
Physical & Chemical Properties Data Field
228.2-233.6 deg F (109-112 deg C)
Etonogestrel (API)
Physical & Chemical Properties Data Field
Freely soluble in 100% ethanol and in dichloromethane; very soluble in methanol; slightly soluble in 96% ethanol and in ethyl acetate; sparingly soluble in hexane.
Etonogestrel (API)
Physical & Chemical Properties Data Field
5.6 (Toral et al., Desogestrel USP SDS)
4.27 (Desogestrel USP SDS)
Etonogestrel (API)
Physical & Chemical Properties Data Field
Stable at normal conditions.
Etonogestrel (API)
Toxicology Data Field
General progestin side effects: Abnormal uterine bleeding; breast enlargement, pain, or tenderness; unexpected or increased flow of breast milk; hot flashes; loss of sexual desires; dry mouth; unusual thirst; frequent urination; abdominal pain; cramping; nausea; loss of appetite; dizziness; headache; mood changes; insomnia; unusual tiredness or weakness; swelling in ankles or feet; unusual or rapid weight gain; skin rash; acne; loss or gain of hair; brown spots on skin; sudden changes in vision.
Etonogestrel (API)
Toxicology Data Field
Mouse oral: > 2000 mg/kg
Rat oral: > 2000 mg/kg
Etonogestrel (API)
Toxicology Data Field
Classified as Group 2B: possibly carcinogenic to humans by IARC
Etonogestrel (API)
Toxicology Data Field
May damage fertility or the unborn child.
Chromosomal abnormalities and congenital malformations may occur in fetuses exposed to progestins.
Progestins may inhibit male and female fertility.
Etonogestrel (API)
Physical & Chemical Properties Data Field
228.2-233.6 °F (109-112 °C)
Desogestrel (API)
Physical & Chemical Properties Data Field
0.5 mg/L water. Freely soluble in 100% ethanol and in dichloromethane; very soluble in methanol; slightly soluble in 96% ethanol and in ethyl acetate; sparingly soluble in hexane.
Desogestrel (API)
Physical & Chemical Properties Data Field
5.6 (Toral et al., Desogestrel USP SDS)
4.27 (Desogestrel USP SDS)
Desogestrel (API)
Toxicology Data Field
General progestin side effects: Abnormal uterine bleeding; breast enlargement, pain, or tenderness; unexpected or increased flow of breast milk; hot flashes; loss of sexual desires; dry mouth; unusual thirst; frequent urination; abdominal pain; cramping; nausea; loss of appetite; dizziness; headache; mood changes; insomnia; unusual tiredness or weakness; swelling in ankles or feet; unusual or rapid weight gain; skin rash; acne; loss or gain of hair; brown spots on skin; sudden changes in vision.
Desogestrel (API)
Toxicology Data Field
No treatment-related tumorigenic effects seen from administration of desogestrel only. Increase in mammary adenocarcinoma in female rats in the high-dose group compared to controls.
Desogestrel (API)
Toxicology Data Field
  • Mouse oral: > 2000 mg/kg
  • Rat oral: > 2000 mg/kg
Desogestrel (API)
Physical & Chemical Properties Data Field
Stable at normal conditions.
Desogestrel (API)