Citations for: DrugBank: Ethinyl Estradiol.
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037

Entry Type
Name
Value
Parent Entry
Identifiers Data Field
DrugBank Accession Number
DB00977
Ethinyl Estradiol (API)
Pharmacology Data Field
Enzyme Interactions
  • Inhibits CYP2C9, CYP2C19, CYP3A4, CYP2B6
  • After formation of very reactive intermediate by oxidation of C17 ethinyl, can irreversibly inhibit cytochrome P450 enzymes (e.g. CYP2C8, CYP3A4). Thus it exerts strong effects on hepatic metabolism.
  • Nuclear receptor subfamily 1 group I member 2: agonist
  • Bile salt export pump: inhibitor, inducer
  • Sodium/bile acid cotransporter: inducer
  • Canalicular multispecific organic anion transporter 1: inducer
  • Multidrug resistance protein 1: substrate
  • Uridine diphosphate glucuronosyltransferase (UGT): inducer
Ethinyl Estradiol (API)