Entry Type
Name
Value
Parent Entry
Pharmacology Data Field
Partial antagonist (about 30% activity of cyproterone acetate)
Drospirenone (API)
Pharmacology Data Field
76-85%
Drospirenone (API)
Pharmacology Data Field
25-33 h
Drospirenone (API)
Pharmacology Data Field
95-96% bound to serum albumin. No binding to SHBG or CBG.
Drospirenone (API)
Pharmacology Data Field
At least 20 different metabolites observed in urine and feces. Metabolites generated independently of the cytochrome P450 system, with only minor metabolism by CYP3A4.
Drospirenone (API)
Pharmacology Data Field
Excreted mostly as glucuronide and sulfate conjugates in urine and feces.
Drospirenone (API)
Pharmacology Data Field
Antagonist
Chlormadinone Acetate (API)
Pharmacology Data Field
No activity
Chlormadinone Acetate (API)
Pharmacology Data Field
Potent antagonist
Cyproterone Acetate (API)
Pharmacology Data Field
No activity
Cyproterone Acetate (API)
Pharmacology Data Field
Antagonist, weak partial agonist
Megestrol Acetate (API)
Pharmacology Data Field
No activity at clinical doses.
Megestrol Acetate (API)
Pharmacology Data Field
60-87 ng/mL
Drospirenone (API)
Pharmacology Data Field
1-2 h
Drospirenone (API)