Entry Type
Name
Value
Parent Entry
Pharmacology Data Field
- Competitive inhibitor of 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase II (3β-HSDII), which is essential for the biosynthesis of sex steroids and corticosteroids.
- CYP3A4: substrate,
inducer
- CYP2C8, CYP2C9:
inhibitor
Medroxyprogesterone Acetate (API)
Pharmacology Data Field
- Inhibits CYP2C9,
CYP2C19, CYP3A4, CYP2B6
- After formation of very reactive intermediate by oxidation of C17 ethinyl, can irreversibly inhibit cytochrome P450 enzymes (e.g. CYP2C8, CYP3A4). Thus it exerts strong effects on hepatic metabolism.
- Nuclear receptor subfamily 1 group I member 2: agonist
- Bile salt export pump: inhibitor, inducer
- Sodium/bile acid cotransporter: inducer
- Canalicular multispecific organic anion transporter 1:
inducer
- Multidrug resistance protein 1: substrate
- Uridine diphosphate glucuronosyltransferase
(UGT): inducer
Ethinyl Estradiol (API)
Pharmacology Data Field
- CYP3A4: inducer (PubChem, Toxnet), inhibitor (KEGG, Laine et al.)
- CYP3A7, CYP3A5, CYP2C19: inhibitor
Gestodene (API)
Pharmacology Data Field
CYP2C19, CYP3A4: inhibitor
Etonogestrel (API)