Citations for: Siddique, Y. H.; Afzal, M. Genotoxic Potential of Cyproterone Acetate: A Possible Role of Reactive Oxygen Species. Toxicol. Vitr. 2005, 19 (1), 63–68.

Toxicology Data Field

Genotoxicity

Reports vary. Siddique et al. found CPA to be genotoxic to human lymphocytes at 20 and 30 μm using chromosomal aberrations, mitotic index, and sister chromatid exchanges. Reimann et al. did not find CPA to be genotoxic in human lymphocyte assay in vitro and mouse bone marrow micronucleus test in vivo.

Cyproterone Acetate (API)