Toxicology Data Field
Increases risk of breast cancer and coronary heart disease in hormone replacement therapy (HRT) users by disturbing normal signaling of natural androgens which play a protective role against breast cancer. Negative effects on bone density due to glucocorticoid activity. Possible weight gain, increased blood pressure, and cardiovascular complications due to no or very weak antimineralocorticoid activity. As an injectable contraceptive, associated with increased HIV acquisition.
Nervousness, abdominal distress, headache, metrorrhagia, amenorrhoea, libido decreased, dizziness, weight increased, asthenia, injection site reaction.
Medroxyprogesterone Acetate (API)