Citations for: Toxnet: Gestodene.

Entry Type
Name
Value
Parent Entry
Pharmacology Data Field
Bioavailability
99%
Gestodene (API)
Pharmacology Data Field
Elimination Half-Life (t1/2)
12-14 h, 16-18 h
Gestodene (API)
Pharmacology Data Field
Serum Protein Binding
75% to SHBG, 24% to albumin, 0.6% free (exact percentages vary depending on treatment)
Gestodene (API)
Pharmacology Data Field
Metabolism
Hepatic, primarily by CYP3A4
Gestodene (API)
Pharmacology Data Field
Cmax
5.6 ng/L from 0.1 mg gestodene/0.03 mg ethinyl estradiol tablet administered orally.
1.0 ng/mL from 0.025 mg gestodene administered orally.
3.6 ng/mL from 0.075 mg gestodene administered orally.
7.0 ng/mL from 0.125 mg gestodene administered orally.
Gestodene (API)
Pharmacology Data Field
Tmax
0.5 h from 0.1 mg gestodene/0.03 mg ethinyl estradiol tablet administered orally.
1.4-1.9 h for oral administration of 0.025, 0.075, or 0.125 mg gestodene tablets.
Gestodene (API)
Physical & Chemical Properties Data Field
Melting Point
197.9° C
Gestodene (API)
Physical & Chemical Properties Data Field
Specific Optical Rotation
-185.7 (for the sodium D line)
Gestodene (API)
Pharmacology Data Field
Clearance
0.8 mL/min/kg
Gestodene (API)
Pharmacology Data Field
Enzyme Interactions
  • CYP3A4: inducer (PubChem, Toxnet), inhibitor (KEGG, Laine et al.)
  • CYP3A7, CYP3A5, CYP2C19: inhibitor
Gestodene (API)