Entry Type
Name
Value
Parent Entry
Physical & Chemical Properties Data Field
Slightly soluble in ethanol (1 in 120), chloroform (1 in 15), diethyl ether (1 in 400) and dioxane
Levonorgestrel (API)
Physical & Chemical Properties Data Field
3.48
Levonorgestrel (API)
Physical & Chemical Properties Data Field
3.92 x 10-10 mm Hg at 25° C (estimated)
Levonorgestrel (API)
Toxicology Data Field
Levonorgestrel was not found to be mutagenic or genotoxic in the Ames Assay, in vitro mammalian culture assays utilizing mouse lymphoma cells and Chinese hamster ovary cells, and in an in vivo micronucleus assay in mice.
Levonorgestrel (API)
Pharmacology Data Field
100%
Levonorgestrel (API)
Pharmacology Data Field
260 L (Healthy female volunteers under fasting conditions)
1.8 L/kg
Levonorgestrel (API)
Pharmacology Data Field
36 +/- 13 h at steady-state (Toxnet)
28 +/- 6.4 h (Toxnet)
24.4 +/- 5.3 h (adult females, one table of Plan B [0.75 mg levonorgestrel])
22.2 +/- 6.8 h (adolescent females, one table of Plan B [0.75 mg levonorgestrel])
Levonorgestrel (API)
Pharmacology Data Field
45% of LNG and metabolites excreted in the urine and 32% excreted in feces, mostly as glucuronide conjugates
Levonorgestrel (API)