Citations for: USP 40: Ethinyl Estradiol monograph.

Physical & Chemical Properties Data Field

Melting Point

180-186 °C (if polymorphic modification: 142-146 °C)

Ethinyl Estradiol (API)

Physical & Chemical Properties Data Field

Specific Optical Rotation

Pubchem/Toxnet: [3.5°] at 24° C/D (c = 2 in dioxane); [-29.5°] at 24° C/D (c = 2 in pyridine)
USP: -28° to -29.5°, 50 mg/mL in colorless pyridine from a freshly opened container

Ethinyl Estradiol (API)