Citations for: British Pharmacopoeia 2017: Megestrol Acetate monograph.

Entry Type
Name
Value
Parent Entry
Impurity
6-Epimedroxyprogesterone Acetate
N/A
Physical & Chemical Properties Data Field
Appearance
White or almost white, odorless, crystalline powder
Megestrol Acetate (API)
Physical & Chemical Properties Data Field
Melting Point
BP: About 217° C
ChemIDPlus: 214° C
Megestrol Acetate (API)
Physical & Chemical Properties Data Field
Solubility
Practically insoluble in water (2 μg/mL at 37 °C). Very soluble in chloroform. Slightly soluble in diethyl ether and fixed oils. Soluble in acetone, sparingly soluble in ethanol (96%).
Megestrol Acetate (API)
Physical & Chemical Properties Data Field
Specific Optical Rotation
+14.0 to +17.0, dried substance, 2.50 g in methylene chloride diluted to 25.0 mL
+5° in chloroform
Megestrol Acetate (API)
Impurity
Medroxyprogesterone Acetate
N/A
Impurity
Megestrol
N/A
Impurity
D-Homo Megestrol Acetate
N/A
Impurity
6-Methylene Hydroxyprogesterone Acetate
N/A
Impurity
6-Methyl-3,20-dioxopregna-1,4,6-trien-17-yl Acetate
N/A
Impurity
2β,6-Dimethyl-3,20-dioxopregna-4,6-dien-17-yl Acetate
N/A
Impurity
2α,6-dimethyl-3,20-dioxopregna-4,6-dien-17-yl Acetate
N/A
Impurity
2,6-Dimethyl-3,20-dioxopregna-1,4,6-trien-17-yl Acetate
N/A
Impurity
6-Methyl-3,20-dioxopregn-5-en-17-yl Acetate
N/A
Impurity
3,20-Dioxopregna-4-en-17-yl Acetate
N/A
Impurity
Megestrol Acetate Dimer
N/A