6-Epimedroxyprogesterone Acetate
Structure
Other Names & Identifiers
- BP MPA Impurity D
- BP Medroxyprogesterone Injection Impurity D
- BP Medroxyprogesterone Tablets Impurity D
- BP Megestrol Acetate Impurity F
- 6β-methyl-17α-hydroxyprogesteron-17-acetate
CASRN
Molecular Formula
C24H34O4
Molecular Weight
386.532 g/mol
PubChem CID
273700
Structural Difference from API
Inversion of stereocenter at C6 of MPA; epimer of MPA
References
- British Pharmacopoeia 2017: Medroxyprogesterone Acetate monograph (View all citations for this reference)
Source of Impurity
epimerization of MPA
References
Appearance
White to Off-White Solid
References
Melting Point
245-250° C
References
Organic Solubility
Chloroform (Slightly), Methanol (Very Slightly, Heated, Sonicated)
References
Storage Conditions
-20° C Freezer
References
Reaxys ID #
2512641
Limits
1.0% (MPA), 0.3% (Megestrol Acetate)
References
- British Pharmacopoeia 2014: Medroxyprogesterone Acetate API (View all citations for this reference)
- European Pharmacopoeia 8.0 Medroxyprogesterone Acetate API (View all citations for this reference)
- British Pharmacopoeia 2017: Medroxyprogesterone Injection monograph (View all citations for this reference)
- British Pharmacopoeia 2017: Medroxyprogesterone Tablets monograph (View all citations for this reference)
- Chen, L.; Liu, X.; Yang, P. 6β-Methyl-3,20-Dioxopregn-4-En-17-Yl Acetate. Acta Crystallogr. Sect. E Struct. Reports Online 2012, 68 (4), o997–o997. (View all citations for this reference)
- PubChem: 2242-65-1 (View all citations for this reference)
- Guo, F.; Feng, H.; Wang, Y.; Zhang, C.; Li, Y. Characterization of Related Impurities in Megestrol Acetate. J. Pharm. Biomed. Anal. 2006, 41 (4), 1418–1422. (View all citations for this reference)
- British Pharmacopoeia 2017: Megestrol Acetate monograph. (View all citations for this reference)