Progesterone

progesterone

Biochemistry & Pharmacology

Progesterone Receptor Activity

Agonist

References

Androgen Receptor Activity

Antagonist

library_books

References

  1. Africander, D.; Verhoog, N.; Hapgood, J. P., Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception. Steroids 2011, 76 (7), 636-52.
    2. (View all citations for this reference)
  2. Bartsch, V., Gynaecological uses of dienogest alone and in combination with oestrogens. Journal of Medical Drug Reviews 2015, 5, 1-31.
    3. (View all citations for this reference)
  3. Hapgood, J. P.; Africander, D.; Louw, R.; Ray, R. M.; Rohwer, J. M., Potency of progestogens used in hormonal therapy: toward understanding differential actions. J Steroid Biochem Mol Biol 2013, 142, 39-47.
    4. (View all citations for this reference)
  4. Lello, S., Nomegestrol Acetate Pharmacology, Safety Profile and Therapeutic Efficacy. Drugs 2010, 70 (5), 541-559.
    5. (View all citations for this reference)

Estrogen Receptor Activity

Antagonist

library_books

References

  1. Africander, D.; Verhoog, N.; Hapgood, J. P., Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception. Steroids 2011, 76 (7), 636-52.
    2. (View all citations for this reference)
  2. Kuhl, H., Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric 2005, 8 Suppl 1, 3-63.
    3. (View all citations for this reference)
  3. Sitruk-Ware, R., New progestagens for contraceptive use. Hum. Reprod. Update 2006, 12 (2), 169-78.
    4. (View all citations for this reference)
  4. Ruan, X.; Seeger, H.; Mueck, A. O., The pharmacology of nomegestrol acetate. Maturitas 2012, 71 (4), 345-53.
    5. (View all citations for this reference)
  5. Lello, S., Nomegestrol Acetate Pharmacology, Safety Profile and Therapeutic Efficacy. Drugs 2010, 70 (5), 541-559.
    6. (View all citations for this reference)

Glucocorticoid Receptor Activity

"weak partial agonist" (Africander, Hapgood), activates GR "minimally" (Turgeon), "active" (Ruan, Lello)

library_books

References

  1. Africander, D.; Verhoog, N.; Hapgood, J. P., Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception. Steroids 2011, 76 (7), 636-52.
    2. (View all citations for this reference)
  2. Hapgood, J. P.; Africander, D.; Louw, R.; Ray, R. M.; Rohwer, J. M., Potency of progestogens used in hormonal therapy: toward understanding differential actions. J Steroid Biochem Mol Biol 2013, 142, 39-47.
    3. (View all citations for this reference)
  3. Turgeon, J. L.; McDonnell, D. P.; Martin, K. A.; Wise, P. M. Hormone Therapy: Physiological Complexity Belies Therapeutic Simplicity. Science (80-. ). 2004, 304, 1269–1273.
    4. (View all citations for this reference)
  4. Ruan, X.; Seeger, H.; Mueck, A. O., The pharmacology of nomegestrol acetate. Maturitas 2012, 71 (4), 345-53.
    5. (View all citations for this reference)
  5. Lello, S., Nomegestrol Acetate Pharmacology, Safety Profile and Therapeutic Efficacy. Drugs 2010, 70 (5), 541-559.
    6. (View all citations for this reference)

Mineralocorticoid Receptor Activity

"weak partial agonist" (Africander), active agonist (Bartsch). Antagonist.

library_books

References

  1. Africander, D.; Verhoog, N.; Hapgood, J. P., Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception. Steroids 2011, 76 (7), 636-52.
    2. (View all citations for this reference)
  2. Bartsch, V., Gynaecological uses of dienogest alone and in combination with oestrogens. Journal of Medical Drug Reviews 2015, 5, 1-31.
    3. (View all citations for this reference)
  3. Kuhl, H., Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric 2005, 8 Suppl 1, 3-63.
    4. (View all citations for this reference)
  4. Hapgood, J. P.; Africander, D.; Louw, R.; Ray, R. M.; Rohwer, J. M., Potency of progestogens used in hormonal therapy: toward understanding differential actions. J Steroid Biochem Mol Biol 2013, 142, 39-47.
    5. (View all citations for this reference)
  5. Ruan, X.; Seeger, H.; Mueck, A. O., The pharmacology of nomegestrol acetate. Maturitas 2012, 71 (4), 345-53.
    6. (View all citations for this reference)
  6. Lello, S., Nomegestrol Acetate Pharmacology, Safety Profile and Therapeutic Efficacy. Drugs 2010, 70 (5), 541-559.
    7. (View all citations for this reference)