1. APIs
  2. Ethinyl Estradiol
  3. Impurities
  4. 6β-Hydroxyethinyl Estradiol

6β-Hydroxyethinyl Estradiol

Structure

MOL SDF CML

Other Names & Identifiers

  • BP Ethinylestradiol Impurity F
  • 19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,6β,17α-triol
  • norpregna-1,3,5(10)-trien-20-yne-3,6,17-triol
  • 19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,6β,17-triol

CASRN

56324-28-8

Molecular Formula

C20H24O3

library_books

References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)

Molecular Weight

312.40276 g/mol

library_books

References

  1. National Center for Biotechnology Information. PubChem Compound Database; CID=11150565. (View all citations for this reference)

Analytical Data

Flourescence (215/315 nm), HPLC

library_books

References

  1. United States Pharmacopoeia 39, 2015 Revision Bulletin: Drospirenone and Ethinyl Estradiol Tablets. (View all citations for this reference)

Melting Point

201 - 202° C

library_books

References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)

Structural Difference from API

One of the Hs of C6 in EE is replaced with an OH group

library_books

References

  1. BP 2015; vol. I, pages 903 - 905
    2. (View all citations for this reference)

Synonyms

library_books

References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)
  2. National Center for Biotechnology Information. PubChem Compound Database; CID=11150565. (View all citations for this reference)

SOURCE FROM API

Oxidation at C6 of EE

library_books

References

  1. BP 2015; vol. I, pages 903 - 905
    2. (View all citations for this reference)

REAXYS ID NUMBER

6573766

library_books

References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)

PUB CHEM CID NUMBER

11771367

library_books

References

  1. National Center for Biotechnology Information. PubChem Compound Database; CID=11150565. (View all citations for this reference)

Limits

0.15%

References

  1. United States Pharmacopoeia 39, 2015 Revision Bulletin: Drospirenone and Ethinyl Estradiol Tablets. (View all citations for this reference)
  2. British Pharmacopoeia 2017: Ethinylestradiol monograph
    3. (View all citations for this reference)
  3. Segmuller, B. E.; Armstrong, B. L.; Dunphy, R.; Oyler, A. R. Identification of Autoxidation and Photodegradation Products of Ethynylestradiol by on-Line HPLC-NMR and HPLC-MS. J. Pharm. Biomed. Anal. 2000, 23 (5), 927–937. (View all citations for this reference)