8(14)-Dehydrolevonorgestrel
Structure
Other Names & Identifiers
- BP Levonorgestrel Impurity A
- δ8(14)-levonorgestrel
- 13-ethyl-17-hydroxy-18,19-dinor-17α-pregna-4,8(14)-dien-20-yn-3-one
CASRN
1260525-53-8
PubChem CID
13828624
info
library_books
Molecular Formula
C21H26O2
info
References
Molecular Weight
310.44 g/mol
info
References
Structural Difference from API
additional double bond between C8 & C4
References
Source of Impurity
A synthetic side product formed during one of the hydrogenation reactions
library_books
References
- Gorog SH, B. Analysis of Steroids. 38. The use of high-performance liquid chromatography with diode-array UV detection for estimating impurity profiles of steroid drugs. Journal of Chromatography. 1987; 400:177-86. (View all citations for this reference)
- Horvath PB, G.; Brlik, J.; Csehi, A.; Dravecz, F.; Halmos, Z.; Lauko, A.; Renyei, M.; Varga, K.; Gorog, S. Estimation of impurity profiles of drugs and related materials .16. Identification of the side-products of the ethinylation step in the synthesis of contraceptive gestogens. Journal of Pharmaceutical and Biomedical Analysis. 1997; 15:1343-9. (View all citations for this reference)
Limits
0.3%
References
- Gorog SH, B. Analysis of Steroids. 38. The use of high-performance liquid chromatography with diode-array UV detection for estimating impurity profiles of steroid drugs. Journal of Chromatography. 1987; 400:177-86. (View all citations for this reference)
- Horvath PB, G.; Brlik, J.; Csehi, A.; Dravecz, F.; Halmos, Z.; Lauko, A.; Renyei, M.; Varga, K.; Gorog, S. Estimation of impurity profiles of drugs and related materials .16. Identification of the side-products of the ethinylation step in the synthesis of contraceptive gestogens. Journal of Pharmaceutical and Biomedical Analysis. 1997; 15:1343-9. (View all citations for this reference)
- British Pharmacopoeia 2017: Levonorgestrel monograph. (View all citations for this reference)
- Berta, R.; Babjak, M.; Gazdag, M. A Study of Some Practical Aspects of High Temperature Liquid Chromatography in Pharmaceutical Applications. J. Pharm. Biomed. Anal. 2011, 54 (3), 458–462. (View all citations for this reference)