Citations for: Horvath PB, G.; Brlik, J.; Csehi, A.; Dravecz, F.; Halmos, Z.; Lauko, A.; Renyei, M.; Varga, K.; Gorog, S. Estimation of impurity profiles of drugs and related materials .16. Identification of the side-products of the ethinylation step in the synthesis of contraceptive gestogens. Journal of Pharmaceutical and Biomedical Analysis. 1997; 15:1343-9.

Entry Type
Name
Value
Parent Entry
a:1:{i:0;s:3:"160";}
a:1:{i:0;s:3:"160";}
4β,5β-Epoxy-norgestrel (Impurity)
Impurity
4β,5β-Epoxy-norgestrel
N/A
Impurity
13-Ethyl-3-methoxy-18,19-dinor-17α-pregna-1,3,5(10)-trien-20-yn-17-ol
N/A
Impurity
Dimeric Levonorgestrel
N/A
Impurities Data Field
Source of Impurity
Synthetic side product formed during the ethinylation step
Dimeric Levonorgestrel (Impurity)
Impurities Data Field
Source of Impurity
Synthetic side product formed during the ethinylation step
Methoxydienone (Impurity)
Impurities Data Field
Source of Impurity
Synthetic side product formed during the ethinylation step
13-Ethylgon-5(10)-ene-3,17-dione (Impurity)
Impurities Data Field
Source of Impurity
Formed through oxidation of final product and/or intermediates
10β-Hydroxylevonorgestrel (Impurity)
Impurities Data Field
Source of Impurity
Formed through oxidation of final product and/or intermediates
6β-hydroxylevonorgestrel (Impurity)
Impurities Data Field
Source of Impurity
Formed through oxidation of final product and/or intermediates
6α-Hydroxylevonorgestrel (Impurity)
Impurities Data Field
Source of Impurity
Synthetic side product formed during the Birch reduction steporiginating from a side product of the Birch reduction step in the synthesis of norgestrel (ref = Hovrath, 1997, Gorog 1998); over-reduction of phenolic ring A in the Birch reduction step of the synthesis (ref = Gorog, 1998)
3-Deoxolevonorgestrel (Impurity)
Impurities Data Field
Source of Impurity
Synthetic side product formed during the ethinylation of the intermediate 3,17 dione
13-Ethyl-3-ethynyl-18,19-dinor-17α-pregna-3,5-dien-20-yn-17-ol (Impurity)
Impurity
8(14)-Dehydrolevonorgestrel
N/A
Impurities Data Field
Source of Impurity
A synthetic side product formed during one of the hydrogenation reactions
8(14)-Dehydrolevonorgestrel (Impurity)