1. APIs
  2. Levonorgestrel
  3. Impurities
  4. Dimeric Levonorgestrel

Dimeric Levonorgestrel

Structure

MOL SDF CML

Notes

Not identified in pharmacopoeias.

Molecular Formula

C40H54O4

References

Molecular Weight

598.87 g/mol

References

Structural Difference from API

two levonorgestrel molecules linked through C17 ethinyl bridge

References

Source of Impurity

Synthetic side product formed during the ethinylation step

library_books

References

  1. Horvath PB, G.; Brlik, J.; Csehi, A.; Dravecz, F.; Halmos, Z.; Lauko, A.; Renyei, M.; Varga, K.; Gorog, S. Estimation of impurity profiles of drugs and related materials .16. Identification of the side-products of the ethinylation step in the synthesis of contraceptive gestogens. Journal of Pharmaceutical and Biomedical Analysis. 1997; 15:1343-9.
    2. (View all citations for this reference)

References

  1. Horvath PB, G.; Brlik, J.; Csehi, A.; Dravecz, F.; Halmos, Z.; Lauko, A.; Renyei, M.; Varga, K.; Gorog, S. Estimation of impurity profiles of drugs and related materials .16. Identification of the side-products of the ethinylation step in the synthesis of contraceptive gestogens. Journal of Pharmaceutical and Biomedical Analysis. 1997; 15:1343-9.
    2. (View all citations for this reference)