1. APIs
  2. Levonorgestrel
  3. Impurities
  4. Δ6-Levonorgestrel

Δ6-Levonorgestrel

Structure

MOL SDF CML

Other Names & Identifiers

  • BP Levonorgestrel Impurity M
  • 13-ethyl-17-hydroxy-18,19-dinor-17%alpha;-pregna-4,6-dien-20-yn-3-one

CASRN

51087-61-7

Molecular Formula

C21H26O2

References

Molecular Weight

310.44 g/mol

References

Structural Difference from API

double bond between C6 & C7

References

Source of Impurity

oxidative degradation

library_books

References

  1. Görög, S.; Babják, M.; Balogh, G.; Brlik, J.; Dravecz, F.; Gazdag, M.; Horváth, P.; Laukó, A.; Varga, K. Estimation of impurity profiles of drugs and related materials Part 19: Theme with variations. Identification of impurities in 3-oxosteroids. Journal of Pharmaceutical and Biomedical Analysis.1998, 18 (4), 511–525. 1998; 18:511-25.
    2. (View all citations for this reference)

Limits

0.2%

References

  1. British Pharmacopoeia 2017: Levonorgestrel monograph.
    2. (View all citations for this reference)