Citations for: Görög, S.; Babják, M.; Balogh, G.; Brlik, J.; Dravecz, F.; Gazdag, M.; Horváth, P.; Laukó, A.; Varga, K. Estimation of impurity profiles of drugs and related materials Part 19: Theme with variations. Identification of impurities in 3-oxosteroids. Journal of Pharmaceutical and Biomedical Analysis.1998, 18 (4), 511–525. 1998; 18:511-25.

Entry Type
Name
Value
Parent Entry
Impurities Data Field
Source of Impurity
synthetic side product formed by the over-reduction of phenolic ring A in the Birch reduction step
4,5-Dihydro-5α-methoxylevonorgestrel (Impurity)
Impurities Data Field
Source of Impurity
oxidative degradation
Δ6-Levonorgestrel (Impurity)
Impurities Data Field
Source of Impurity
oxidative degradation
6-Oxolevonorgestrel (Impurity)
Impurities Data Field
Source of Impurity
Synthetic side product formed during the Birch reduction steporiginating from a side product of the Birch reduction step in the synthesis of norgestrel (ref = Hovrath, 1997, Gorog 1998); over-reduction of phenolic ring A in the Birch reduction step of the synthesis (ref = Gorog, 1998)
3-Deoxolevonorgestrel (Impurity)
Impurities Data Field
Source of Impurity
Synthetic side product formed during the ethinylation of the intermediate 3,17 dione
13-Ethyl-3-ethynyl-18,19-dinor-17α-pregna-3,5-dien-20-yn-17-ol (Impurity)
Impurities Data Field
Source of Impurity
Synthetic side product formed during the Birch Reduction/hydrolysis
Δ5(10)-8β-Levonorgestrel (Impurity)
Impurity
6α-Hydroxynestorone
N/A
Impurities Data Field
NAME
6α-hydroxynestorone
6α-Hydroxynestorone (Impurity)
Impurities Data Field
SOURCE
Oxidative degradation
6α-Hydroxynestorone (Impurity)
Impurities Data Field
SPECTRA
UV, HPLC Chromatogram
6α-Hydroxynestorone (Impurity)
Impurity
6β-Hydroxynestorone
N/A
Impurities Data Field
NAME
6β-hydroxynestorone
6β-Hydroxynestorone (Impurity)
Impurities Data Field
SOURCE
Oxidative degradation
6β-Hydroxynestorone (Impurity)
Impurities Data Field
SPECTRA
UV, HPLC
6β-Hydroxynestorone (Impurity)
Impurity
6-Oxonestorone
N/A
Impurities Data Field
SPECTRA
UV, HPLC
6-Oxonestorone (Impurity)
Impurity
6-Ene Nestorone Derivative
N/A
Impurities Data Field
SPECTRA
UV, HPLC
6-Ene Nestorone Derivative (Impurity)
Impurity
10β-Hydroxynestorone
N/A
Impurities Data Field
NAME
10β-hydroxynestorone
10β-Hydroxynestorone (Impurity)
Impurities Data Field
SOURCE
Oxidative degradation
10β-Hydroxynestorone (Impurity)
Impurities Data Field
SPECTRA
UV shifts
10β-Hydroxynestorone (Impurity)
Impurity
8-Ene Nestorone Derivative
N/A
Impurities Data Field
SPECTRA
UV shifts
8-Ene Nestorone Derivative (Impurity)
Impurities Data Field
SOURCE
From total synthesis
8-Ene Nestorone Derivative (Impurity)
Impurity
4,6,8(14)-Triene Nestorone Derivative
N/A
Impurities Data Field
SPECTRA
UV shift
4,6,8(14)-Triene Nestorone Derivative (Impurity)
Impurity
3-Deoxo-3-ethynyl-3,5-diene Nestorone Derivative
N/A
Impurities Data Field
SPECTRA
UV shift
3-Deoxo-3-ethynyl-3,5-diene Nestorone Derivative (Impurity)
Impurity
3-Deoxonestorone
N/A
Impurities Data Field
NAME
3-deoxonestorone
3-Deoxonestorone (Impurity)
Impurities Data Field
SPECTRA
UV Inactive
3-Deoxonestorone (Impurity)
Impurities Data Field
SOURCE
Birch reduction
3-Deoxonestorone (Impurity)
Impurity
1-Ene-3-one Nestorone Derivative
N/A
Impurities Data Field
SPECTRA
UV shift
1-Ene-3-one Nestorone Derivative (Impurity)
Impurities Data Field
SOURCE
Birch reduction
1-Ene-3-one Nestorone Derivative (Impurity)
Impurity
5(10)-Ene-3-one Nestorone Derivative
N/A
Impurities Data Field
SPECTRA
UV inactive
5(10)-Ene-3-one Nestorone Derivative (Impurity)
Impurities Data Field
SOURCE
Birch reduction
5(10)-Ene-3-one Nestorone Derivative (Impurity)
Impurity
4,5-Dihydronestorone
N/A
Impurities Data Field
NAME
4,5-dihydronestorone
4,5-Dihydronestorone (Impurity)
Impurities Data Field
SPECTRA
UV inactive
4,5-Dihydronestorone (Impurity)
Impurities Data Field
SOURCE
Birch reduction
4,5-Dihydronestorone (Impurity)
Impurities Data Field
SOURCE
Total synthesis/degradation
4,6,8(14)-Triene Nestorone Derivative (Impurity)
Analytical Method
UV Spectra
N/A