1. APIs
  2. Levonorgestrel
  3. Impurities
  4. 4,5-Dihydro-5α-methoxylevonorgestrel

4,5-Dihydro-5α-methoxylevonorgestrel

Structure

MOL SDF CML

Other Names & Identifiers

  • BP Levonorgestrel Impurity O
  • 13-ethyl-17-hydroxy-5α-methoxy-18,19-dinor-17α-pregn-20-yn-3-one

Molecular Formula

C22H32O3

References

Molecular Weight

344.49 g/mol

References

Structural Difference from API

no double bond between C4 & C5; methoxy group at C5

References

Source of Impurity

synthetic side product formed by the over-reduction of phenolic ring A in the Birch reduction step

library_books

References

  1. Görög, S.; Babják, M.; Balogh, G.; Brlik, J.; Dravecz, F.; Gazdag, M.; Horváth, P.; Laukó, A.; Varga, K. Estimation of impurity profiles of drugs and related materials Part 19: Theme with variations. Identification of impurities in 3-oxosteroids. Journal of Pharmaceutical and Biomedical Analysis.1998, 18 (4), 511–525. 1998; 18:511-25.
    2. (View all citations for this reference)

Pub Chem ID

71316193

References

Limits

0.3%

References

  1. British Pharmacopoeia 2017: Levonorgestrel monograph.
    2. (View all citations for this reference)