1. APIs
  2. Desogestrel
  3. Metabolites
  4. Etonogestrel

Etonogestrel

Structure

CASRN

54048-10-1

Notes

Primary metabolite of desogestrel, resulting from the rapid oxidation of desogestrel metabolites 3α- and 3β-hydroxydesogestrel by 3β-hydroxysteroid dehydrogenase/Delta 5-->4 isomerase type 1.

References

  1. DrugBank: Desogestrel
    Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037     (View all citations for this reference)
  2. Grandi, G.; Cagnacci, A.; Volpe, A. Pharmacokinetic Evaluation of Desogestrel as a Female Contraceptive. Expert Opin. Drug Metab. Toxicol. 2014, 10 (1), 1–10. (View all citations for this reference)
  3. Gentile, D. M.; Verhoeven, C. H. J.; Shimada, T.; Back, D. J. The Role of CYP2C in the in Vitro Bioactivation of the Contraceptive Steroid Desogestrel. J. Pharmacol. Exp. Ther. 1998, 287 (3), 975–982.
    4. (View all citations for this reference)
  4. Schindler, A. E.; Campagnoli, C.; Druckmann, R.; Huber, J.; Pasqualini, J. R.; Schweppe, K. W.; Thijssen, J. H. H., Classification and pharmacology of progestins. Maturitas 2003, 46, 7-16.
    5. (View all citations for this reference)
  5. Verhoeven, C. H. J.; Krebbers, S. F. M.; Wagenaars, G. N.; Vos, R. M. E. In Vitro and in Vivo Metabolism of Desogestrel in Several Species. DRUG Metab. Dispos. 1998, 26 (9), 927–936.
    6. (View all citations for this reference)