Citations for: DrugBank: Estradiol
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037

Entry Type

Name

Value

Parent Entry

Physical & Chemical Properties Data Field

Melting Point

178.5° C (ChemIDPlus, Toxnet)
151-152° C (DrugBank)

Estradiol (API)

Physical & Chemical Properties Data Field

logP

4.01

Estradiol (API)

Pharmacology Data Field

Elimination Half-Life (t_1/2)

Oral: 13-30 h (Stanczyk)
36 h (DrugBank)
20.1 h from oral administration (Toxnet)

Estradiol (API)

Metabolites

2-Hydroxyestradiol

N/A

Metabolites

4-Hydroxyestradiol

N/A

Identifiers Data Field

DrugBank Accession Number

DB00783

Estradiol (API)

Pharmacology Data Field

Other

-4.77

Estradiol (API)

Pharmacology Data Field

Indications

For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).

Estradiol (API)