Citations for: Larrea, F.; Garcia-Becerra, R.; Lemus, A. E.; Garcia, G. A.; Perez-Palacios, G.; Jackson, K. J.; Coleman, K. M.; Dace, R.; Smith, C. L.; Cooney, A. J., A-ring reduced metabolites of 19-nor synthetic progestins as subtype selective agonists for ER alpha. Endocrinology 2001, 142 (9), 3791-3799.

Entry Type
Name
Value
Parent Entry
Metabolites
3β,5α-tetrahydrolevonorgestrel
N/A
Metabolites
3β,5α-tetrahydrogestodene
N/A
Metabolites
5α-dihydrogestodene
N/A
Metabolites
3α,5α-tetrahydrogestodene
N/A
Metabolites Data Field
Progestogen Receptor Activity
Significantly reduced progestational activity
3β,5α-Tetrahydronorethindrone (Metabolite)
Metabolites Data Field
Estrogen Receptor Activity
selectively activates ERα. "Able to activate gene transcription via ER, although its binding affinity is lower than estradiol."
3β,5α-Tetrahydronorethindrone (Metabolite)
Metabolites Data Field
Progestogen Receptor Activity
Relatively high binding affinity to PR but significantly reduced progestational activity from NET.
5α-Dihydronorethindrone (Metabolite)