1. APIs
  2. Norethindrone
  3. Analytical Methods
  4. Mass Spectrometry of Certain Impurities of Norethindrone, Norgestrel, and Ethinyl Estradiol
  1. APIs
  2. Norgestrel
  3. Analytical Methods
  4. Mass Spectrometry of Certain Impurities of Norethindrone, Norgestrel, and Ethinyl Estradiol
  1. APIs
  2. Ethinyl Estradiol
  3. Ethinyl Estradiol Analytical Methods
  4. Mass Spectrometry of Certain Impurities of Norethindrone, Norgestrel, and Ethinyl Estradiol

Mass Spectrometry of Certain Impurities of Norethindrone, Norgestrel, and Ethinyl Estradiol

Analytical Test

Identification

Analytical Technique

Mass Spectrometry

Impurities and/or Metabolites Involved

Related Methods

Experimental Setting Value
Mass Spectrometer Kratos MS-80/DS-55
Ionization method (Ethinyl estradiol and norgestrel impurities) Chemical ionization; reagent gas: ammonia, 250 eV, 2500 μA
Ionization method (norethindrone impurities) Electron impact, 70 eV, 100 μA
Ion Source Temperature 200-240° C
Compound Relevant API Relative Retention Time Detection λ Intensity
9(11)-Dehydroethinyl Estradiol Ethinyl Estradiol 0.89 280 -

References

  1. Gorog SH, B. Analysis of Steroids. 38. The use of high-performance liquid chromatography with diode-array UV detection for estimating impurity profiles of steroid drugs. Journal of Chromatography. 1987; 400:177-86.
    2. (View all citations for this reference)