6-Methylenehydroxyprogesterone Acetate
Structure
Other Names & Identifiers
- BP MPA Impurity E
- BP Medroxyprogesterone Injection Impurity E
- BP Medroxyprogesterone Tablets Impurity E
- 17-acetoxy-6-methylene-4-pregnene-3,20-dione
- 6-methylidene-3,20-dioxopregn-4-en-17-yl acetate
CASRN
Molecular Formula
C24H32O4
Molecular Weight
384.52 g/mol
Source of Impurity
Oxidation of MPA; removal of H2
References
Structural Difference from API
a methylene (CH2) group is attached at C6 of MPA
References
- British Pharmacopea 2015; Volume II pages 179 through 199; pertains to MPA and its impurities (View all citations for this reference)
Appearance
White Solid
References
Melting Point
230-233° C
References
Organic Solubility
Chloroform, Methanol
References
Storage Conditions
Refrigerator
References
Specific Optical Rotation
226° in Chloroform
Reaxys ID #
4573716
Enzyme Interactions
3-oxo-5α-steroid 4-dehydrogenase inhibitor
Limits
0.2%
References
- British Pharmacopoeia 2014: Medroxyprogesterone Acetate API (View all citations for this reference)
- European Pharmacopoeia 8.0 Medroxyprogesterone Acetate API (View all citations for this reference)
- British Pharmacopoeia 2017: Medroxyprogesterone Acetate monograph (View all citations for this reference)
- British Pharmacopoeia 2017: Medroxyprogesterone Injection monograph (View all citations for this reference)
- British Pharmacopoeia 2017: Medroxyprogesterone Tablets monograph (View all citations for this reference)