4,5-Dihydromedroxyprogesterone Acetate
Structure
Other Names & Identifiers
- BP MPA Impurity F
- BP Medroxyprogesterone Injection Impurity F
- BP Medroxyprogesterone Tablets Impurity F
- USP MPA Related Compound A
- 17α-acetoxy-6α-methyl-5β-pregnane-3,20-dione
- 6α-methyl-3,20-dioxo-5β-pregnan-17-yl acetate
CASRN
Molecular Formula
C24H36O4
Molecular Weight
388.55 g/mol
Structural Difference from API
The C4=C5 double bond of MPA is replaced with a C4-C5 single bond.
References
- British Pharmacopea 2015; Volume II pages 179 through 199; pertains to MPA and its impurities (View all citations for this reference)
Source of Impurity
reduction of MPA; addition of H2 to the C4=C5 double bond of MPA
References
Appearance
White to Off-White Solid
References
Melting Point
183-185° C
References
Storage Conditions
Refrigerator
References
Organic Solubility
Chloroform (Slightly), Methanol (Slightly)
References
Reaxys ID #
5304845
Limits
0.10%
References
- British Pharmacopoeia 2014: Medroxyprogesterone Acetate API (View all citations for this reference)
- European Pharmacopoeia 8.0 Medroxyprogesterone Acetate API (View all citations for this reference)
- British Pharmacopoeia 2017: Medroxyprogesterone Acetate monograph (View all citations for this reference)
- British Pharmacopoeia 2017: Medroxyprogesterone Injection monograph (View all citations for this reference)
- United States Pharmacopoeia 36 (2013): Medroxyprogesterone Acetate. (View all citations for this reference)
- British Pharmacopoeia 2017: Medroxyprogesterone Tablets monograph (View all citations for this reference)
- PubChem: 22295786 (View all citations for this reference)