1. APIs
  2. Medroxy­progesterone Acetate
  3. Impurities
  4. Hydroxyprogesterone acetate

Hydroxyprogesterone acetate

Structure

MOL SDF CML

Other Names & Identifiers

  • BP MPA Impurity H
  • 17α-acetoxy-pregn-4-ene-3,20-dione
  • 3,20-dioxopregn-4-en-17-yl acetate

CASRN

17308-02-0

Molecular Formula

C23H32O4

References

Molecular Weight

372.51 g/mol

References

Structural Difference from API

The methyl group on C6 of MPA is replaced with an H group

library_books

References

  1. British Pharmacopoeia 2017: Medroxyprogesterone Acetate monograph
    2. (View all citations for this reference)

Source of Impurity

Demethylation of MPA; direct or indirect removal of MPA's C6 methyl group

References

Melting Point

243 - 244° C

library_books

References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)

Specific Optical Rotation

[α] 60°, 589 nm, 20° C

library_books

References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)

Reaxys ID #

2227870

library_books

References

  1. Online Subscription Database. Reed Elsevier Properties SA. (View all citations for this reference)

Limits

0.1%

References

  1. British Pharmacopoeia 2014: Medroxyprogesterone Acetate API
    2. (View all citations for this reference)
  2. European Pharmacopoeia 8.0 Medroxyprogesterone Acetate API
    3. (View all citations for this reference)
  3. British Pharmacopoeia 2017: Medroxyprogesterone Acetate monograph
    4. (View all citations for this reference)