1. APIs
  2. Medroxy­progesterone Acetate
  3. Impurities
  4. 17β-Hydroxy-6,17α-dimethyl-D-homoandrost-4-en-3,17-dione

17β-Hydroxy-6,17α-dimethyl-D-homoandrost-4-en-3,17-dione

Structure

MOL SDF CML

Other Names & Identifiers

  • BP MPA Impurity I

Molecular Formula

C22H32O3

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References

  1. Online free access database provided by the United States National Institutes of Health (NIH). (View all citations for this reference)

Molecular Weight

344.49 g/mol

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References

  1. Online free access database provided by the United States National Institutes of Health (NIH). (View all citations for this reference)

Structural Difference from API

5-membered ring expands to a 6-membered ring

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References

  1. British Pharmacopoeia 2017: Medroxyprogesterone Acetate monograph
    2. (View all citations for this reference)

Source of Impurity

possible rearrangement of MPA

References

Limits

0.2%

References

  1. British Pharmacopoeia 2014: Medroxyprogesterone Acetate API
    2. (View all citations for this reference)
  2. European Pharmacopoeia 8.0 Medroxyprogesterone Acetate API
    3. (View all citations for this reference)
  3. British Pharmacopoeia 2017: Medroxyprogesterone Acetate monograph
    4. (View all citations for this reference)