2-hydroxyethinyl estradiol

Structure

Source

Hydroxylation by CYP3A4

Notes

Major metabolite. Formed by CYP3A4. Can be converted to the methoxy EE by catechol O-methyltransferase.

References

  1. Kuhl, H., Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric 2005, 8 Suppl 1, 3-63.
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  3. Stanczyk FZ. All progestins are not created equal. Steroids. 2003; 68:879-90.
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  5. Ethinyl Estradiol. Toxicology Data Network. US National Library of Medicine [Online Database] (View all citations for this reference)