1. APIs
  2. Estradiol
  3. Estradiol Metabolites
  4. Estrone

Estrone

Structure

MOL SDF CML

CASRN

53-16-7

Source

Conversion by 17β-hydroxysteroid dehydrogenase.

Notes

Formed in the liver by CYP2C9, CYP2C19, and CYP2C8. Undergoes further conversion to estriol, the major urinary metabolite. 10 times less potent estrogen agonist that estradiol.

References

  1. Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e, 2011 > Estrogens and Progestins. Laurence L. Brunton, Bruce A. Chabner, Björn C. Knollmann.
    2. (View all citations for this reference)
  2. Wikipedia: Estradiol (View all citations for this reference)
  3. Toxnet: Estradiol. (View all citations for this reference)