Citations for: Toxnet: Estradiol.

Entry Type
Name
Value
Parent Entry
Physical & Chemical Properties Data Field
178.5° C (ChemIDPlus, Toxnet)
151-152° C (DrugBank)
Estradiol (API)
Physical & Chemical Properties Data Field
3.9 mg/L water at 27° C. Freely soluble in alcohol,;soluble in acetone, dioxane, other organic solvents; sparingly soluble in vegetable oils.
Estradiol (API)
Metabolites
N/A
Metabolites
N/A
Physical & Chemical Properties Data Field
4.01
Estradiol (API)
Pharmacology Data Field
Oral: 13-30 h (Stanczyk)
36 h (DrugBank)
20.1 h from oral administration (Toxnet)
Estradiol (API)
Pharmacology Data Field
60% to albumin, 38% to SHBG.
Estradiol (API)
Pharmacology Data Field
Hepatic, if oral administration.
Estradiol (API)
Pharmacology Data Field
54% in urine, 6% in feces.
Estradiol (API)
Physical & Chemical Properties Data Field
143°–150°
Estradiol Valerate (API)
Toxicology Data Field
"There is sufficient evidence in humans for the carcinogenicity of post-menopausal estrogen therapy. There is sufficient evidence in experimental animals for the carcinogenicity of estradiol and estrone."
Estradiol (API)
Physical & Chemical Properties Data Field
+76 - +83° at 25 °C for D (sodium) line (dioxane)
Estradiol (API)
Physical & Chemical Properties Data Field
225, 280 nm
Estradiol (API)