3β,5α-tetrahydrolevonorgestrel |
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Estrogenic activity. Significantly reduced progestational activity. |
2α-hydroxylevonorgestrel |
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Also present as glucuronide conjugate. |
13-ethyl-4-homogonane-3,17-dione |
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Also present as sulfate and glucuronide conjugates. |
16β-hydroxy-3α,5β-tetrahydrolevonorgestrel |
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Also present as sulfate and glucuronide conjugates. |
16β-Hydroxylevonorgestrel |
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Sulfate conjugate also present, as well as the sulfate conjugate of the 16α stereoisomer. Metabolite of both levonorgestrel and norgestrel. |
3β,5β-tetrahydrolevonorgestrel |
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Minor metabolite. Also present as a sulfate conjugate. |
3α,5β-tetrahydrolevonorgestrel |
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Major metabolite. Also found as sulfate and glucuronide conjugates. |
3α,5α-tetrahydrolevonorgestrel |
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"Much smaller" amount present than the primary metabolite 3α,5β-tetrahydrolevonorgestrel. Sulfate and glucuronide conjugates are also present. Tetrahydrometabolites of LNG are reported to show estrogenic activity in vitro. |