Citations for: Besse, J. P.; Garric, J., Progestagens for human use, exposure and hazard assessment for the aquatic environment. Environ. Pollut. 2009, 157 (12), 3485-3494.

Entry Type
Name
Value
Parent Entry
SAR_13 ()
SAR_12 ()
Reduces androgenicity and enhances progestagenicity
SAR_12 ()
SAR_11 ()
Reduces androgenicity and enhances progestagenicity
SAR_11 ()
SAR_9 ()
SAR_8 ()
Delays metabolization
SAR_8 ()
SAR_7 ()
Enhances metabolization
SAR_7 ()
SAR_6 ()
Delays metabolization
SAR_6 ()
SAR_5 ()
Delays metabolization
SAR_5 ()
SAR_4 ()
SAR_3 ()
Reduction or abolition of the progestagenic activity
SAR_3 ()
SAR_14 ()
Anti-aromatase activity of P4 (anti-androgenic activity)
SAR_14 ()
SAR_15 ()
Appearance of estrogenic activity
SAR_15 ()
SAR_16 ()
Switch from progestagenic activity to estrogenic activity
SAR_16 ()
SAR_17 ()
Necessary for displaying estrogenic activity
SAR_17 ()
SAR_2 ()
Reduction then abolition of the progestagenic activity
SAR_2 ()
SAR_1 ()
Essential for binding to progesterone receptor
SAR_1 ()
SAR_10 ()
Enhances metabolization enhancement in androgen and glucocorticoid binding due to an overall decrease in affinity for other receptors
SAR_10 ()
Metabolites
3α,5α-tetrahydrolevonorgestrel
N/A
Metabolites
3α,5β-tetrahydrolevonorgestrel
N/A
Metabolites
16β-Hydroxylevonorgestrel
N/A
Metabolites
Other MPA Metabolites
N/A
Metabolites
3β,5α-tetrahydrolevonorgestrel
N/A
Physical & Chemical Properties Data Field
Molecular Formula
Test value
Levonorgestrel (API)
Metabolites
3α,5α-Tetrahydronorethindrone
N/A
Metabolites
3α,5β-Tetrahydronorethindrone
N/A
Metabolites
3β,5α-Tetrahydronorethindrone
N/A
Metabolites
3β,5β-Tetrahydronorethindrone
N/A
Metabolites
5β-Dihydronorethindrone
N/A
Metabolites
5α-Dihydronorethindrone
N/A
Pharmacology Data Field
Excretion
Only 1% excreted unchanged in urine.
Gestodene (API)
Metabolites
3β-Hydroxychlormadinone Acetate
N/A
Metabolites
15β-Hydroxycyproterone Acetate
N/A
Metabolites Data Field
Androgen Receptor Activity
Antagonist
3β-Hydroxychlormadinone Acetate (Metabolite)
Metabolites Data Field
Androgen Receptor Activity
Antagonist
15β-Hydroxycyproterone Acetate (Metabolite)